p63 EEC Syndrome

p63 EEC International Network Word Communication Onlus

Ectrodactyly - Ectodermal Dysplasia - Cleft Syndrome

  • ita
  • eng
  • spa

EEC Syndrome - Story



The syndrome Ectrodactyly-ectodermal dysplasia-cleft palate (EEC) is a rare congenital malformation pathology characterized by the association of ectrodactyly (anomaly limb in which some central rays of the hands are missing with appearance of "clamp hand" or "crab claw hand"), abnormalities of the palate and abnormalities of the tissues ectodermal derivation. The ectoderm is the package outer embryonic tissue from which they originally nervous and epithelial tissues covering (epidermis, epithelium corneal etc..) and appendages (hair,nails, etc...)

Signs and Symptoms

Concerning the facies, frequent abnormalities of the naso-lacrimal duct, the genitourinary system and major anomalies of the extremities, from ectrodactily to syndactily (fusion of fingers and toes).

A load of facial cleft lip and cleft palate may be at present. The ectodermal part of this syndrome involves hair, teeth and nails. The hypohidrosis is variable, although often the skin is dry and hyperkeratosis may be present the palms of hands and feet. The hair is sparse, clear and dry eyelashes and eyebrows are often lacking. Teeth are small and can be partially formed and there can be hypodontia and anodontia. The nails are thin, fragile and marked; frequently found abnormalities of tear duct. Nardi and colleagues found abnormalities in 13 to 25 genitourinary cases. These abnormalities included: megaureter, vescicoureteric reflux, hydronephrosis and hypospadias. Mental development is usually normal, the cleft, in most cases in the form of cleft lip and palate, is frequent, but not essential part of the syndrome. All features are highly variable and must be placed carefully examining and advise the parents of the patient, who may appear as an isolated case. Van Maldergem, Kuna and colleagues revealed an abnormal hypothalamic-pituitary function. (R. M. Winter, M. Baraitser, London Dysmorphology Database, Oxford Medical Databases, 2000). The ocular manifestations are a component found frequently in EEC syndrome. (Ireland et al. Ophthalmic Manifestations of ectodermal dysplasia-ectrodactyly-clefting syndrome. Ophthalmic-plast, reconstr-surg. 1998, 14 / 4 (295-297) and (Colin Willoughby, unpublished data).


The disease is linked to gene mutations p63, deputy the production of a protein essential for both (i) during the embryogenesis of the normal developement of the ectoderm, and (ii) in adult for the maturation and differentiation of the staminal cells of various epithelial tissues including cornea, where the 'expression of p63 is restricted at the basal layer of the limbus, the niche cells corneal stem cells and stem cells when cultured laboratory(Figg. 8a, 8b). Most cases are sporadic, associated with de novo mutations, which typically arise during the development of 'embryo. Familial cases show a type of autosomal dominant inheritance variable penetrance.

The incidence and the prevalence of the disease in the Italian population not are known. Males and females are equally affected.

Fig. 8a

figura 8a


Fig. 8b

figura 8b


Eye problems

During childhood the main features that put at a disadvantage a patient suffering from EEC syndrome are cleft palate and deformities of the hand with its surgical corrections. During young adulthood, however, the eye problems become prevalent aspects of disability: patients often show alterations of the ocular surface (blepharitis and conjunctivitis), dysfunction of corneal epithelium and poor re-epithelization following trauma and penetrating keratoplasty (Fig.9).



figura 9


These patients have a vascularized corneal pannus that leads to a progressive decrease of vision to complete loss of vision (Figg.10a, 10b).

figura 10a
figura 10b
figura 11